Individual participant data (IPD)-level meta-analysis of randomised controlled trials with vitamin D-fortified foods to estimate Dietary Reference Values for vitamin D
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Individual participant data (IPD)-level meta-analysis of randomised controlled trials with vitamin D-fortified foods to estimate Dietary Reference Values for vitamin D. / Cashman, Kevin D; Kiely, Mairead E; Andersen, Rikke; Grønborg, Ida M; Madsen, Katja Howarth; Nissen, Janna; Tetens, Inge; Tripkovic, Laura; Lanham-New, Susan A; Toxqui, Laura; Vaquero, M Pilar; Trautvetter, Ulrike; Jahreis, Gerhard; Mistry, Vikram V; Specker, Bonny L; Hower, Jürgen; Knoll, Anette; Wagner, Dennis; Vieth, Reinhold; Öhlund, Inger; Karlsland Åkeson, Pia; Brett, Neil R; Weiler, Hope A; Ritz, Christian.
In: European Journal of Nutrition, Vol. 60, No. 2, 2021, p. 939-959.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Individual participant data (IPD)-level meta-analysis of randomised controlled trials with vitamin D-fortified foods to estimate Dietary Reference Values for vitamin D
AU - Cashman, Kevin D
AU - Kiely, Mairead E
AU - Andersen, Rikke
AU - Grønborg, Ida M
AU - Madsen, Katja Howarth
AU - Nissen, Janna
AU - Tetens, Inge
AU - Tripkovic, Laura
AU - Lanham-New, Susan A
AU - Toxqui, Laura
AU - Vaquero, M Pilar
AU - Trautvetter, Ulrike
AU - Jahreis, Gerhard
AU - Mistry, Vikram V
AU - Specker, Bonny L
AU - Hower, Jürgen
AU - Knoll, Anette
AU - Wagner, Dennis
AU - Vieth, Reinhold
AU - Öhlund, Inger
AU - Karlsland Åkeson, Pia
AU - Brett, Neil R
AU - Weiler, Hope A
AU - Ritz, Christian
N1 - CURIS 2021 NEXS 078
PY - 2021
Y1 - 2021
N2 - Context and purpose: Individual participant data-level meta-regression (IPD) analysis is superior to meta-regression based on aggregate data in determining Dietary Reference Values (DRV) for vitamin D. Using data from randomized controlled trials (RCTs) with vitamin D3-fortified foods, we undertook an IPD analysis of the response of winter serum 25-hydroxyvitamin (25(OH)D) to total vitamin D intake among children and adults and derived DRV for vitamin D.Methods: IPD analysis using data from 1429 participants (ages 2-89 years) in 11 RCTs with vitamin D-fortified foods identified via a systematic review and predefined eligibility criteria. Outcome measures were vitamin D DRV estimates across a range of serum 25(OH)D thresholds using unadjusted and adjusted models.Results: Our IPD-derived estimates of vitamin D intakes required to maintain 97.5% of winter 25(OH)D concentrations ≥ 25 and ≥ 30 nmol/L are 6 and 12 µg/day, respectively (unadjusted model). The intake estimates to maintain 90%, 95% and 97.5% of concentrations ≥ 50 nmol/L are 33.4, 57.5 and 92.3 µg/day, respectively (unadjusted) and 17.0, 28.1 and 43.6 µg/day, respectively (adjusted for mean values for baseline serum 25(OH)D, age and BMI).Conclusions: IPD-derived vitamin D intakes required to maintain 90%, 95% and 97.5% of winter 25(OH)D concentrations ≥ 50 nmol/L are much higher than those derived from standard meta-regression based on aggregate data, due to the inability of the latter to capture between person-variability. Our IPD provides further evidence that using food-based approaches to achieve an intake of 12 µg/day could prevent vitamin D deficiency (i.e., serum 25(OH)D < 30 nmol/L) in the general population.
AB - Context and purpose: Individual participant data-level meta-regression (IPD) analysis is superior to meta-regression based on aggregate data in determining Dietary Reference Values (DRV) for vitamin D. Using data from randomized controlled trials (RCTs) with vitamin D3-fortified foods, we undertook an IPD analysis of the response of winter serum 25-hydroxyvitamin (25(OH)D) to total vitamin D intake among children and adults and derived DRV for vitamin D.Methods: IPD analysis using data from 1429 participants (ages 2-89 years) in 11 RCTs with vitamin D-fortified foods identified via a systematic review and predefined eligibility criteria. Outcome measures were vitamin D DRV estimates across a range of serum 25(OH)D thresholds using unadjusted and adjusted models.Results: Our IPD-derived estimates of vitamin D intakes required to maintain 97.5% of winter 25(OH)D concentrations ≥ 25 and ≥ 30 nmol/L are 6 and 12 µg/day, respectively (unadjusted model). The intake estimates to maintain 90%, 95% and 97.5% of concentrations ≥ 50 nmol/L are 33.4, 57.5 and 92.3 µg/day, respectively (unadjusted) and 17.0, 28.1 and 43.6 µg/day, respectively (adjusted for mean values for baseline serum 25(OH)D, age and BMI).Conclusions: IPD-derived vitamin D intakes required to maintain 90%, 95% and 97.5% of winter 25(OH)D concentrations ≥ 50 nmol/L are much higher than those derived from standard meta-regression based on aggregate data, due to the inability of the latter to capture between person-variability. Our IPD provides further evidence that using food-based approaches to achieve an intake of 12 µg/day could prevent vitamin D deficiency (i.e., serum 25(OH)D < 30 nmol/L) in the general population.
KW - Faculty of Science
KW - Vitamin D recommendations
KW - Dietary reference values
KW - Recommended dietary allowance
KW - Individual Participant Data-level meta-regression analyses
KW - Vitamin D-fortified foods
U2 - 10.1007/s00394-020-02298-x
DO - 10.1007/s00394-020-02298-x
M3 - Journal article
C2 - 32556447
VL - 60
SP - 939
EP - 959
JO - European Journal of Nutrition
JF - European Journal of Nutrition
SN - 1436-6207
IS - 2
ER -
ID: 243340836