Is GLUT4 translocation the answer to exercise stimulated muscle glucose uptake?
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Is GLUT4 translocation the answer to exercise stimulated muscle glucose uptake? / Richter, Erik A.
In: American Journal of Physiology: Endocrinology and Metabolism, Vol. 320, No. 2, 2021, p. E240-E243.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Is GLUT4 translocation the answer to exercise stimulated muscle glucose uptake?
AU - Richter, Erik A.
N1 - CURIS 2021 NEXS 033
PY - 2021
Y1 - 2021
N2 - Exercise increases muscle glucose uptake up to 100 fold compared to rest. The magnitude of increase depends on exercise intensity and duration. While KO of GLUT4 convincingly has shown that GLUT4 is necessary for exercise to increase muscle glucose uptake, studies only show an approximate 2-fold increase in GLUT4 translocation to the muscle cell membrane when transitioning from rest to exercise. Therefore, there is a big discrepancy between the increase in glucose uptake and GLUT4 translocation. It is suggested that either the methods for measurements of GLUT4 translocation in muscle grossly underestimate the real translocation of GLUT4 or alternatively that GLUT4 intrinsic activity increases in muscle during exercise, perhaps due to increased muscle temperature and/or mechanical effects during contraction/relaxation cycles.
AB - Exercise increases muscle glucose uptake up to 100 fold compared to rest. The magnitude of increase depends on exercise intensity and duration. While KO of GLUT4 convincingly has shown that GLUT4 is necessary for exercise to increase muscle glucose uptake, studies only show an approximate 2-fold increase in GLUT4 translocation to the muscle cell membrane when transitioning from rest to exercise. Therefore, there is a big discrepancy between the increase in glucose uptake and GLUT4 translocation. It is suggested that either the methods for measurements of GLUT4 translocation in muscle grossly underestimate the real translocation of GLUT4 or alternatively that GLUT4 intrinsic activity increases in muscle during exercise, perhaps due to increased muscle temperature and/or mechanical effects during contraction/relaxation cycles.
KW - Faculty of Science
KW - Muscle glucose uptake
KW - Exercise
KW - GLUT4
KW - Glucose transport
KW - GLUT4 translocation
U2 - 10.1152/ajpendo.00503.2020
DO - 10.1152/ajpendo.00503.2020
M3 - Journal article
C2 - 33166188
VL - 320
SP - E240-E243
JO - American Journal of Physiology - Endocrinology and Metabolism
JF - American Journal of Physiology - Endocrinology and Metabolism
SN - 0193-1849
IS - 2
ER -
ID: 251309578