Predictors of glucose metabolism and blood pressure among Ethiopian individuals with HIV/AIDS after one-year antiretroviral therapy
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Predictors of glucose metabolism and blood pressure among Ethiopian individuals with HIV/AIDS after one-year antiretroviral therapy. / Amare, Hiwot; Olsen, Mette Frahm; Friis, Henrik; Andersen, Åse B; Abdissa, Alemseged; Yilma, Daniel; Girma, Tsinuel; Faurholt-Jepsen, Daniel.
In: Tropical Medicine & International Health, Vol. 26, No. 4, 2021, p. 428-434.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Predictors of glucose metabolism and blood pressure among Ethiopian individuals with HIV/AIDS after one-year antiretroviral therapy
AU - Amare, Hiwot
AU - Olsen, Mette Frahm
AU - Friis, Henrik
AU - Andersen, Åse B
AU - Abdissa, Alemseged
AU - Yilma, Daniel
AU - Girma, Tsinuel
AU - Faurholt-Jepsen, Daniel
N1 - This article is protected by copyright. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Objective: Better understanding of glucose metabolism in HIV patients after initiating anti-retroviral therapy (ART) is important to target treatment and follow-up for diabetes risk and other non-communicable diseases in resource-limited settings. The aim of this study was to assess the changes and predictors of glucose metabolism and blood pressure among HIV patients on ART for 12 months.Methods: One-year follow-up of Ethiopian HIV patients after initiation of ART was done. Outcomes were changes in fasting plasma glucose (FPG), and 30-minute (30mPG) and 2-hour plasma glucose (2hPG) after oral glucose tolerance test, glycated hemoglobin (HbA1c), fasting plasma insulin (p-insulin), homeostatic model assessment index for insulin resistance (HOMA-IR) and blood pressure. The mean age was 33 years and the majority were women.Results: During the first 12 months, levels of all plasma glucose parameters decreased, while p-insulin (10B 3.1; 95% CI2.4, 4.0), HOMA-IR (10B 3.1; 95% CI2.3, 4.0), and systolic blood pressure (B 4.0; 95%CI2.5, 5.5) increased. Fat-free mass at baseline predicted higher increments in p-insulin, HOMA-IR and blood pressure, whereas fat mass predicted higher increment in HbA1c.Conclusions: Among Ethiopian HIV patients, blood pressure and insulin increased and all glucose parameters declined during 12-month of ART. Only longer-term follow-up will tell us whether insulin increase is due to insulin resistance or from recovering β-cells.
AB - Objective: Better understanding of glucose metabolism in HIV patients after initiating anti-retroviral therapy (ART) is important to target treatment and follow-up for diabetes risk and other non-communicable diseases in resource-limited settings. The aim of this study was to assess the changes and predictors of glucose metabolism and blood pressure among HIV patients on ART for 12 months.Methods: One-year follow-up of Ethiopian HIV patients after initiation of ART was done. Outcomes were changes in fasting plasma glucose (FPG), and 30-minute (30mPG) and 2-hour plasma glucose (2hPG) after oral glucose tolerance test, glycated hemoglobin (HbA1c), fasting plasma insulin (p-insulin), homeostatic model assessment index for insulin resistance (HOMA-IR) and blood pressure. The mean age was 33 years and the majority were women.Results: During the first 12 months, levels of all plasma glucose parameters decreased, while p-insulin (10B 3.1; 95% CI2.4, 4.0), HOMA-IR (10B 3.1; 95% CI2.3, 4.0), and systolic blood pressure (B 4.0; 95%CI2.5, 5.5) increased. Fat-free mass at baseline predicted higher increments in p-insulin, HOMA-IR and blood pressure, whereas fat mass predicted higher increment in HbA1c.Conclusions: Among Ethiopian HIV patients, blood pressure and insulin increased and all glucose parameters declined during 12-month of ART. Only longer-term follow-up will tell us whether insulin increase is due to insulin resistance or from recovering β-cells.
KW - Faculty of Science
KW - Glucose metabolism
KW - Blood pressure
KW - HIV
KW - ART
KW - β‐cells
KW - Ethiopia
KW - Sustainable Development Goals (SDGs): 3.3, 3.4
U2 - 10.1111/tmi.13544
DO - 10.1111/tmi.13544
M3 - Journal article
C2 - 33405245
VL - 26
SP - 428
EP - 434
JO - Tropical Medicine & International Health
JF - Tropical Medicine & International Health
SN - 1360-2276
IS - 4
ER -
ID: 255043095