Protection of 4-hydroxybenzyl-chitooligomers against inflammatory responses in Chang liver cells
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Protection of 4-hydroxybenzyl-chitooligomers against inflammatory responses in Chang liver cells. / Trinh, Mai Duy Luu; Dinh, Minh-Hiep; Ngo, Dai-Hung; Tran, Dang-Khoa; Tran, Quoc-Tuan; Vo, Thanh-Sang; Ngo, Dai-Nghiep.
In: International Journal of Biological Macromolecules, Vol. 66, 09.02.2014, p. 1-6.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Protection of 4-hydroxybenzyl-chitooligomers against inflammatory responses in Chang liver cells
AU - Trinh, Mai Duy Luu
AU - Dinh, Minh-Hiep
AU - Ngo, Dai-Hung
AU - Tran, Dang-Khoa
AU - Tran, Quoc-Tuan
AU - Vo, Thanh-Sang
AU - Ngo, Dai-Nghiep
PY - 2014/2/9
Y1 - 2014/2/9
N2 - The aim of this study was to investigate anti-inflammatory activity of 4-hydroxybenzyl-chitooligomers (HB-COS) in Chang liver cells stimulated by a cytokine mixture. It was revealed that HB-COS decreased the level of nitric oxide and prostaglandin E2 (PGE2) production by diminishing the expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) without significant cytotoxicity. Moreover, HB-COS exerted inhibitory effects on the production of pro-inflammatory mediator (interleukin-6) in Chang liver cells. Notably, HB-COS exhibited anti-inflammatory activities via blocking degradation of inhibitory kappa B alpha (IκB-α), translocation of nuclear factor kappa B (NF-κB), and phosphorylation of mitogen-activated protein kinases (MAPKs) in a dose-dependent manner. Collectively, these findings indicated that HB-COS possessed potential anti-inflammatory effects in Chang liver cells, and could be a useful therapeutic agent for the treatment of hepatic inflammatory diseases.
AB - The aim of this study was to investigate anti-inflammatory activity of 4-hydroxybenzyl-chitooligomers (HB-COS) in Chang liver cells stimulated by a cytokine mixture. It was revealed that HB-COS decreased the level of nitric oxide and prostaglandin E2 (PGE2) production by diminishing the expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) without significant cytotoxicity. Moreover, HB-COS exerted inhibitory effects on the production of pro-inflammatory mediator (interleukin-6) in Chang liver cells. Notably, HB-COS exhibited anti-inflammatory activities via blocking degradation of inhibitory kappa B alpha (IκB-α), translocation of nuclear factor kappa B (NF-κB), and phosphorylation of mitogen-activated protein kinases (MAPKs) in a dose-dependent manner. Collectively, these findings indicated that HB-COS possessed potential anti-inflammatory effects in Chang liver cells, and could be a useful therapeutic agent for the treatment of hepatic inflammatory diseases.
KW - Faculty of Science
KW - Anti-inflammation
KW - 4-Hydroxybenzyl-chitooligomers
KW - Chang liver cells
KW - iNOS
KW - COX-2
UR - http://dx.doi.org/10.1016/j.ijbiomac.2014.01.064
U2 - 10.1016/j.ijbiomac.2014.01.064
DO - 10.1016/j.ijbiomac.2014.01.064
M3 - Journal article
VL - 66
SP - 1
EP - 6
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
SN - 0141-8130
ER -
ID: 311345080