Protection of 4-hydroxybenzyl-chitooligomers against inflammatory responses in Chang liver cells
Research output: Contribution to journal › Journal article › Research › peer-review
The aim of this study was to investigate anti-inflammatory activity of 4-hydroxybenzyl-chitooligomers (HB-COS) in Chang liver cells stimulated by a cytokine mixture. It was revealed that HB-COS decreased the level of nitric oxide and prostaglandin E2 (PGE2) production by diminishing the expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) without significant cytotoxicity. Moreover, HB-COS exerted inhibitory effects on the production of pro-inflammatory mediator (interleukin-6) in Chang liver cells. Notably, HB-COS exhibited anti-inflammatory activities via blocking degradation of inhibitory kappa B alpha (IκB-α), translocation of nuclear factor kappa B (NF-κB), and phosphorylation of mitogen-activated protein kinases (MAPKs) in a dose-dependent manner. Collectively, these findings indicated that HB-COS possessed potential anti-inflammatory effects in Chang liver cells, and could be a useful therapeutic agent for the treatment of hepatic inflammatory diseases.
Original language | English |
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Journal | International Journal of Biological Macromolecules |
Volume | 66 |
Pages (from-to) | 1-6 |
ISSN | 0141-8130 |
DOIs | |
Publication status | Published - 9 Feb 2014 |
Externally published | Yes |
- Faculty of Science - Anti-inflammation, 4-Hydroxybenzyl-chitooligomers, Chang liver cells, iNOS, COX-2
Research areas
ID: 311345080