A Genetic Analysis of Crystal Growth
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
A Genetic Analysis of Crystal Growth. / Brown, Stanley; Sarikaya, Mehmet; Johnson, E.
In: Journal of Molecular Biology, Vol. 299, No. 3, 2000, p. 725-735.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - A Genetic Analysis of Crystal Growth
AU - Brown, Stanley
AU - Sarikaya, Mehmet
AU - Johnson, E.
N1 - Keywords: gold; crystal morphology; peptide display
PY - 2000
Y1 - 2000
N2 - The regulation of crystal morphology by proteins is often observed in biology. It is a central feature in the formation of hard tissues such as bones, teeth and mollusc shells. We have developed a genetic system in the bacterium Escherichia coli to study the protein-mediated control of crystal growth. We have used the crystallization of gold as a model system and found polypeptides that control the morphology of the resulting gold crystals. Analysis of the crystallization process influenced by these polypeptides indicates they act catalytically by an acid mechanism. Our results suggest that the concepts and methods of microbial genetics are general and can be applied to substances not commonly found in biological systems.
AB - The regulation of crystal morphology by proteins is often observed in biology. It is a central feature in the formation of hard tissues such as bones, teeth and mollusc shells. We have developed a genetic system in the bacterium Escherichia coli to study the protein-mediated control of crystal growth. We have used the crystallization of gold as a model system and found polypeptides that control the morphology of the resulting gold crystals. Analysis of the crystallization process influenced by these polypeptides indicates they act catalytically by an acid mechanism. Our results suggest that the concepts and methods of microbial genetics are general and can be applied to substances not commonly found in biological systems.
U2 - 10.1006/jmbi.2000.3682
DO - 10.1006/jmbi.2000.3682
M3 - Journal article
VL - 299
SP - 725
EP - 735
JO - Journal of Molecular Biology
JF - Journal of Molecular Biology
SN - 0022-2836
IS - 3
ER -
ID: 185393