Faf1 is expressed during neurodevelopment and is involved in Apaf1-dependent caspase-3 activation in proneural cells

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Faf1 is expressed during neurodevelopment and is involved in Apaf1-dependent caspase-3 activation in proneural cells. / De Zio, D.; Ferraro, E.; D'Amelio, M.; Simoni, V.; Bordi, M.; Soroldoni, D.; Berghella, L.; Meyer, B. I.; Cecconi, F.

In: Cellular and Molecular Life Sciences, Vol. 65, No. 11, 06.2008, p. 1780-1790.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

De Zio, D, Ferraro, E, D'Amelio, M, Simoni, V, Bordi, M, Soroldoni, D, Berghella, L, Meyer, BI & Cecconi, F 2008, 'Faf1 is expressed during neurodevelopment and is involved in Apaf1-dependent caspase-3 activation in proneural cells', Cellular and Molecular Life Sciences, vol. 65, no. 11, pp. 1780-1790. https://doi.org/10.1007/s00018-008-8075-5

APA

De Zio, D., Ferraro, E., D'Amelio, M., Simoni, V., Bordi, M., Soroldoni, D., Berghella, L., Meyer, B. I., & Cecconi, F. (2008). Faf1 is expressed during neurodevelopment and is involved in Apaf1-dependent caspase-3 activation in proneural cells. Cellular and Molecular Life Sciences, 65(11), 1780-1790. https://doi.org/10.1007/s00018-008-8075-5

Vancouver

De Zio D, Ferraro E, D'Amelio M, Simoni V, Bordi M, Soroldoni D et al. Faf1 is expressed during neurodevelopment and is involved in Apaf1-dependent caspase-3 activation in proneural cells. Cellular and Molecular Life Sciences. 2008 Jun;65(11):1780-1790. https://doi.org/10.1007/s00018-008-8075-5

Author

De Zio, D. ; Ferraro, E. ; D'Amelio, M. ; Simoni, V. ; Bordi, M. ; Soroldoni, D. ; Berghella, L. ; Meyer, B. I. ; Cecconi, F. / Faf1 is expressed during neurodevelopment and is involved in Apaf1-dependent caspase-3 activation in proneural cells. In: Cellular and Molecular Life Sciences. 2008 ; Vol. 65, No. 11. pp. 1780-1790.

Bibtex

@article{4620de95dc6d4c96a2a6612c67babbbe,
title = "Faf1 is expressed during neurodevelopment and is involved in Apaf1-dependent caspase-3 activation in proneural cells",
abstract = "Fas-associated factor 1 (Faf1) has been described as a Fas-binding pro-apoptotic protein and as a component of the death-inducing signaling complex (DISC) in Fas-mediated apoptosis. Faf1 is able to potentiate Fas-induced apoptosis in several cell lines, although its specific functions are still not clear. Here we show that Faf1 is highly expressed in several areas of the developing telencephalon. Its expression pattern appears to be dynamic at different embryonic stages and to be progressively confined within limited territories. To decipher the specific role of Faf1 in developing brain, we used cDNA over-expression and mRNA down-regulation experiments to modulate Faf1 expression in telencephalic neural precursor cells, and we showed that in neural cell death Faf1 acts as a Fas-independent apoptotic enhancer. Moreover, we found that Faf1 protein level is down-regulated during apoptosis in a caspase- and Apaf1-dependent manner.",
keywords = "Apaf1, Apoptosis, Caspase(s), Cell death, Neurodevelopment",
author = "{De Zio}, D. and E. Ferraro and M. D'Amelio and V. Simoni and M. Bordi and D. Soroldoni and L. Berghella and Meyer, {B. I.} and F. Cecconi",
year = "2008",
month = jun,
doi = "10.1007/s00018-008-8075-5",
language = "English",
volume = "65",
pages = "1780--1790",
journal = "Critical Sociology",
issn = "0896-9205",
publisher = "SAGE Publications",
number = "11",

}

RIS

TY - JOUR

T1 - Faf1 is expressed during neurodevelopment and is involved in Apaf1-dependent caspase-3 activation in proneural cells

AU - De Zio, D.

AU - Ferraro, E.

AU - D'Amelio, M.

AU - Simoni, V.

AU - Bordi, M.

AU - Soroldoni, D.

AU - Berghella, L.

AU - Meyer, B. I.

AU - Cecconi, F.

PY - 2008/6

Y1 - 2008/6

N2 - Fas-associated factor 1 (Faf1) has been described as a Fas-binding pro-apoptotic protein and as a component of the death-inducing signaling complex (DISC) in Fas-mediated apoptosis. Faf1 is able to potentiate Fas-induced apoptosis in several cell lines, although its specific functions are still not clear. Here we show that Faf1 is highly expressed in several areas of the developing telencephalon. Its expression pattern appears to be dynamic at different embryonic stages and to be progressively confined within limited territories. To decipher the specific role of Faf1 in developing brain, we used cDNA over-expression and mRNA down-regulation experiments to modulate Faf1 expression in telencephalic neural precursor cells, and we showed that in neural cell death Faf1 acts as a Fas-independent apoptotic enhancer. Moreover, we found that Faf1 protein level is down-regulated during apoptosis in a caspase- and Apaf1-dependent manner.

AB - Fas-associated factor 1 (Faf1) has been described as a Fas-binding pro-apoptotic protein and as a component of the death-inducing signaling complex (DISC) in Fas-mediated apoptosis. Faf1 is able to potentiate Fas-induced apoptosis in several cell lines, although its specific functions are still not clear. Here we show that Faf1 is highly expressed in several areas of the developing telencephalon. Its expression pattern appears to be dynamic at different embryonic stages and to be progressively confined within limited territories. To decipher the specific role of Faf1 in developing brain, we used cDNA over-expression and mRNA down-regulation experiments to modulate Faf1 expression in telencephalic neural precursor cells, and we showed that in neural cell death Faf1 acts as a Fas-independent apoptotic enhancer. Moreover, we found that Faf1 protein level is down-regulated during apoptosis in a caspase- and Apaf1-dependent manner.

KW - Apaf1

KW - Apoptosis

KW - Caspase(s)

KW - Cell death

KW - Neurodevelopment

UR - http://www.scopus.com/inward/record.url?scp=44749090748&partnerID=8YFLogxK

U2 - 10.1007/s00018-008-8075-5

DO - 10.1007/s00018-008-8075-5

M3 - Journal article

C2 - 18480964

AN - SCOPUS:44749090748

VL - 65

SP - 1780

EP - 1790

JO - Critical Sociology

JF - Critical Sociology

SN - 0896-9205

IS - 11

ER -

ID: 338889403