Prognostic significance of urokinase-type plasminogen activator and plasminogen activator inhibitor-1 in primary breast cancer
Research output: Contribution to journal › Journal article › Research › peer-review
The uPA-mediated pathway of plasminogen activation is central to cancer metastasis. Whether uPA and PAI-1 are related to local recurrence, metastatic spread or both is not clear. We present a retrospective study of 429 primary breast cancer patients with a median follow-up of 5.1 years, in which the levels of uPA and PAI-1 in tumour extracts were analysed by means of an enzyme-linked immunosorbent assay. The median values of uPA and PAI-1, which were used as cut-off points, were 4.5 and 11.1 ng mg(-1) protein respectively. The levels of uPA and PAI-1 were correlated with tumour size, degree of anaplasia, steroid receptor status and number of positive nodes. Patients with high content of either uPA or PAI-1 had increased risk of relapse and death. We demonstrated an independent ability of PAI-1 to predict distant metastasis (relative risk 1.7, confidence limits 1.22 and 2.46) and that neither uPA nor PAI-1 provided any information regarding local recurrence.
Original language | English |
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Journal | British Journal of Cancer |
Volume | 77 |
Issue number | 6 |
Pages (from-to) | 932-40 |
Number of pages | 9 |
ISSN | 0007-0920 |
DOIs | |
Publication status | Published - Mar 1998 |
- Adult, Aged, Breast Neoplasms/enzymology, Carcinoma, Intraductal, Noninfiltrating/enzymology, Cell Differentiation, Enzyme-Linked Immunosorbent Assay, Female, Follow-Up Studies, Humans, Lymph Nodes/pathology, Lymphatic Metastasis, Middle Aged, Neoplasm Invasiveness, Neoplasm Metastasis, Plasminogen Activator Inhibitor 1/analysis, Predictive Value of Tests, Prognosis, Receptors, Estrogen, Receptors, Progesterone, Risk Assessment, Sensitivity and Specificity, Statistics, Nonparametric, Survival Analysis, Time Factors, Urokinase-Type Plasminogen Activator/analysis
Research areas
ID: 259933154