Coexistence of phage and bacteria on the boundary of self-organized refuges

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Coexistence of phage and bacteria on the boundary of self-organized refuges. / Heilmann, Silja; Sneppen, Kim; Krishna, Sandeep.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, No. 31, 31.07.2012, p. 12828-33.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Heilmann, S, Sneppen, K & Krishna, S 2012, 'Coexistence of phage and bacteria on the boundary of self-organized refuges', Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 31, pp. 12828-33. https://doi.org/10.1073/pnas.1200771109

APA

Heilmann, S., Sneppen, K., & Krishna, S. (2012). Coexistence of phage and bacteria on the boundary of self-organized refuges. Proceedings of the National Academy of Sciences of the United States of America, 109(31), 12828-33. https://doi.org/10.1073/pnas.1200771109

Vancouver

Heilmann S, Sneppen K, Krishna S. Coexistence of phage and bacteria on the boundary of self-organized refuges. Proceedings of the National Academy of Sciences of the United States of America. 2012 Jul 31;109(31):12828-33. https://doi.org/10.1073/pnas.1200771109

Author

Heilmann, Silja ; Sneppen, Kim ; Krishna, Sandeep. / Coexistence of phage and bacteria on the boundary of self-organized refuges. In: Proceedings of the National Academy of Sciences of the United States of America. 2012 ; Vol. 109, No. 31. pp. 12828-33.

Bibtex

@article{f344243460d448b0bdcdf79dcdf53814,
title = "Coexistence of phage and bacteria on the boundary of self-organized refuges",
abstract = "Bacteriophage are voracious predators of bacteria and a major determinant in shaping bacterial life strategies. Many phage species are virulent, meaning that infection leads to certain death of the host and immediate release of a large batch of phage progeny. Despite this apparent voraciousness, bacteria have stably coexisted with virulent phages for eons. Here, using individual-based stochastic spatial models, we study the conditions for achieving coexistence on the edge between two habitats, one of which is a bacterial refuge with conditions hostile to phage whereas the other is phage friendly. We show how bacterial density-dependent, or quorum-sensing, mechanisms such as the formation of biofilm can produce such refuges and edges in a self-organized manner. Coexistence on these edges exhibits the following properties, all of which are observed in real phage-bacteria ecosystems but difficult to achieve together in nonspatial ecosystem models: (i) highly efficient virulent phage with relatively long lifetimes, high infection rates and large burst sizes; (ii) large, stable, and high-density populations of phage and bacteria; (iii) a fast turnover of both phage and bacteria; and (iv) stability over evolutionary timescales despite imbalances in the rates of phage vs. bacterial evolution.",
keywords = "Bacteria/virology, Bacterial Physiological Phenomena, Bacteriophages/physiology, Biological Evolution, Ecosystem, Models, Biological, Quorum Sensing/physiology",
author = "Silja Heilmann and Kim Sneppen and Sandeep Krishna",
year = "2012",
month = jul,
day = "31",
doi = "10.1073/pnas.1200771109",
language = "English",
volume = "109",
pages = "12828--33",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "The National Academy of Sciences of the United States of America",
number = "31",

}

RIS

TY - JOUR

T1 - Coexistence of phage and bacteria on the boundary of self-organized refuges

AU - Heilmann, Silja

AU - Sneppen, Kim

AU - Krishna, Sandeep

PY - 2012/7/31

Y1 - 2012/7/31

N2 - Bacteriophage are voracious predators of bacteria and a major determinant in shaping bacterial life strategies. Many phage species are virulent, meaning that infection leads to certain death of the host and immediate release of a large batch of phage progeny. Despite this apparent voraciousness, bacteria have stably coexisted with virulent phages for eons. Here, using individual-based stochastic spatial models, we study the conditions for achieving coexistence on the edge between two habitats, one of which is a bacterial refuge with conditions hostile to phage whereas the other is phage friendly. We show how bacterial density-dependent, or quorum-sensing, mechanisms such as the formation of biofilm can produce such refuges and edges in a self-organized manner. Coexistence on these edges exhibits the following properties, all of which are observed in real phage-bacteria ecosystems but difficult to achieve together in nonspatial ecosystem models: (i) highly efficient virulent phage with relatively long lifetimes, high infection rates and large burst sizes; (ii) large, stable, and high-density populations of phage and bacteria; (iii) a fast turnover of both phage and bacteria; and (iv) stability over evolutionary timescales despite imbalances in the rates of phage vs. bacterial evolution.

AB - Bacteriophage are voracious predators of bacteria and a major determinant in shaping bacterial life strategies. Many phage species are virulent, meaning that infection leads to certain death of the host and immediate release of a large batch of phage progeny. Despite this apparent voraciousness, bacteria have stably coexisted with virulent phages for eons. Here, using individual-based stochastic spatial models, we study the conditions for achieving coexistence on the edge between two habitats, one of which is a bacterial refuge with conditions hostile to phage whereas the other is phage friendly. We show how bacterial density-dependent, or quorum-sensing, mechanisms such as the formation of biofilm can produce such refuges and edges in a self-organized manner. Coexistence on these edges exhibits the following properties, all of which are observed in real phage-bacteria ecosystems but difficult to achieve together in nonspatial ecosystem models: (i) highly efficient virulent phage with relatively long lifetimes, high infection rates and large burst sizes; (ii) large, stable, and high-density populations of phage and bacteria; (iii) a fast turnover of both phage and bacteria; and (iv) stability over evolutionary timescales despite imbalances in the rates of phage vs. bacterial evolution.

KW - Bacteria/virology

KW - Bacterial Physiological Phenomena

KW - Bacteriophages/physiology

KW - Biological Evolution

KW - Ecosystem

KW - Models, Biological

KW - Quorum Sensing/physiology

U2 - 10.1073/pnas.1200771109

DO - 10.1073/pnas.1200771109

M3 - Journal article

C2 - 22807479

VL - 109

SP - 12828

EP - 12833

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 31

ER -

ID: 226495239