Temperature Controls Onset and Period of NF-kappa B Oscillations and can Lead to Chaotic Dynamics

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Temperature Controls Onset and Period of NF-kappa B Oscillations and can Lead to Chaotic Dynamics. / Heltberg, Mathias; von Borries, Mads; Bendix, Poul Martin; Oddershede, Lene B.; Jensen, Mogens H.

In: Frontiers in Cell and Developmental Biology, Vol. 10, 910738, 20.06.2022.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Heltberg, M, von Borries, M, Bendix, PM, Oddershede, LB & Jensen, MH 2022, 'Temperature Controls Onset and Period of NF-kappa B Oscillations and can Lead to Chaotic Dynamics', Frontiers in Cell and Developmental Biology, vol. 10, 910738. https://doi.org/10.3389/fcell.2022.910738

APA

Heltberg, M., von Borries, M., Bendix, P. M., Oddershede, L. B., & Jensen, M. H. (2022). Temperature Controls Onset and Period of NF-kappa B Oscillations and can Lead to Chaotic Dynamics. Frontiers in Cell and Developmental Biology, 10, [910738]. https://doi.org/10.3389/fcell.2022.910738

Vancouver

Heltberg M, von Borries M, Bendix PM, Oddershede LB, Jensen MH. Temperature Controls Onset and Period of NF-kappa B Oscillations and can Lead to Chaotic Dynamics. Frontiers in Cell and Developmental Biology. 2022 Jun 20;10. 910738. https://doi.org/10.3389/fcell.2022.910738

Author

Heltberg, Mathias ; von Borries, Mads ; Bendix, Poul Martin ; Oddershede, Lene B. ; Jensen, Mogens H. / Temperature Controls Onset and Period of NF-kappa B Oscillations and can Lead to Chaotic Dynamics. In: Frontiers in Cell and Developmental Biology. 2022 ; Vol. 10.

Bibtex

@article{c8f0a7ff3ced41b08e6cc08b6cd09196,
title = "Temperature Controls Onset and Period of NF-kappa B Oscillations and can Lead to Chaotic Dynamics",
abstract = "The transcription factor NF-kappa B plays a vital role in the control of the immune system, and following stimulation with TNF-alpha its nuclear concentration shows oscillatory behaviour. How environmental factors, in particular temperature, can control the oscillations and thereby affect gene stimulation is still remains to be resolved question. In this work, we reveal that the period of the oscillations decreases with increasing temperature. We investigate this using a mathematical model, and by applying results from statistical physics, we introduce temperature dependency to all rates, resulting in a remarkable correspondence between model and experiments. Our model predicts how temperature affects downstream protein production and find a crossover, where high affinity genes upregulates at high temperatures. Finally, we show how or that oscillatory temperatures can entrain NF-kappa B oscillations and lead to chaotic dynamics presenting a simple path to chaotic conditions in cellular biology.",
keywords = "dynamical systems, oscillations, gene regulation, controllability, chaos, transcription factors, NF-kB, CIRCADIAN-RHYTHMS, COMPENSATION, LOCKING, STRESS, MODEL",
author = "Mathias Heltberg and {von Borries}, Mads and Bendix, {Poul Martin} and Oddershede, {Lene B.} and Jensen, {Mogens H.}",
year = "2022",
month = jun,
day = "20",
doi = "10.3389/fcell.2022.910738",
language = "English",
volume = "10",
journal = "Frontiers in Cell and Developmental Biology",
issn = "2296-634X",
publisher = "Frontiers Media",

}

RIS

TY - JOUR

T1 - Temperature Controls Onset and Period of NF-kappa B Oscillations and can Lead to Chaotic Dynamics

AU - Heltberg, Mathias

AU - von Borries, Mads

AU - Bendix, Poul Martin

AU - Oddershede, Lene B.

AU - Jensen, Mogens H.

PY - 2022/6/20

Y1 - 2022/6/20

N2 - The transcription factor NF-kappa B plays a vital role in the control of the immune system, and following stimulation with TNF-alpha its nuclear concentration shows oscillatory behaviour. How environmental factors, in particular temperature, can control the oscillations and thereby affect gene stimulation is still remains to be resolved question. In this work, we reveal that the period of the oscillations decreases with increasing temperature. We investigate this using a mathematical model, and by applying results from statistical physics, we introduce temperature dependency to all rates, resulting in a remarkable correspondence between model and experiments. Our model predicts how temperature affects downstream protein production and find a crossover, where high affinity genes upregulates at high temperatures. Finally, we show how or that oscillatory temperatures can entrain NF-kappa B oscillations and lead to chaotic dynamics presenting a simple path to chaotic conditions in cellular biology.

AB - The transcription factor NF-kappa B plays a vital role in the control of the immune system, and following stimulation with TNF-alpha its nuclear concentration shows oscillatory behaviour. How environmental factors, in particular temperature, can control the oscillations and thereby affect gene stimulation is still remains to be resolved question. In this work, we reveal that the period of the oscillations decreases with increasing temperature. We investigate this using a mathematical model, and by applying results from statistical physics, we introduce temperature dependency to all rates, resulting in a remarkable correspondence between model and experiments. Our model predicts how temperature affects downstream protein production and find a crossover, where high affinity genes upregulates at high temperatures. Finally, we show how or that oscillatory temperatures can entrain NF-kappa B oscillations and lead to chaotic dynamics presenting a simple path to chaotic conditions in cellular biology.

KW - dynamical systems

KW - oscillations

KW - gene regulation

KW - controllability

KW - chaos

KW - transcription factors

KW - NF-kB

KW - CIRCADIAN-RHYTHMS

KW - COMPENSATION

KW - LOCKING

KW - STRESS

KW - MODEL

U2 - 10.3389/fcell.2022.910738

DO - 10.3389/fcell.2022.910738

M3 - Journal article

C2 - 35794861

VL - 10

JO - Frontiers in Cell and Developmental Biology

JF - Frontiers in Cell and Developmental Biology

SN - 2296-634X

M1 - 910738

ER -

ID: 315460472