A versatile approach to beta-amyloid fibril-binding compounds exploiting the Shirakawa/Hayashi protocol for trans-alkene synthesis
Research output: Contribution to journal › Journal article › Research › peer-review
Application of the Sonogashira coupling reaction followed by a trans-selective alkyne reduction proved highly adaptable for the efficient synthesis of a class of beta-amyloid fibril binding compounds possessing a styrylbenzene motif such as FSB, an FSB dimer, and (19)F-BAY94-9172.
| Original language | English |
|---|---|
| Journal | Organic Letters |
| Volume | 11 |
| Issue number | 4 |
| Pages (from-to) | 999-1002 |
| Number of pages | 4 |
| ISSN | 1523-7060 |
| DOIs | |
| Publication status | Published - 19 Feb 2009 |
- Alkenes/chemical synthesis, Alkynes/chemistry, Amyloid beta-Peptides/metabolism, Aniline Compounds/chemical synthesis, Molecular Structure, Protein Binding, Stereoisomerism, Stilbenes/chemical synthesis, Styrenes/chemical synthesis
Research areas
ID: 325014054