TY - JOUR

T1 - Curvature strains as a global orchestrator of morphogenesis

AU - Kirkegaard, Julius B.

PY - 2022/5/31

Y1 - 2022/5/31

N2 - Successful morphogenesis on the scale of organs or organisms requires strict coordination between the constituent cells whose action on the local scale must be orchestrated accurately to achieve a functional shape on the global scale. We present a theoretical model in which morphogenetic information is encoded only through a locally preferred curvature, but with cell dynamics which simultaneously ensures that these interactions globally achieve morphogenesis and correct cell-neighbor exchanges to avoid cell stretches. This is achieved by a cell-cell interaction potential that drives correct cell intercalation to reorganize the cell sheet dynamically during the deformation processes. We demonstrate morphogenesis of simple three-dimensional shapes and study the effects of fixed cell neighbor connectivity and noisy cell division.

AB - Successful morphogenesis on the scale of organs or organisms requires strict coordination between the constituent cells whose action on the local scale must be orchestrated accurately to achieve a functional shape on the global scale. We present a theoretical model in which morphogenetic information is encoded only through a locally preferred curvature, but with cell dynamics which simultaneously ensures that these interactions globally achieve morphogenesis and correct cell-neighbor exchanges to avoid cell stretches. This is achieved by a cell-cell interaction potential that drives correct cell intercalation to reorganize the cell sheet dynamically during the deformation processes. We demonstrate morphogenesis of simple three-dimensional shapes and study the effects of fixed cell neighbor connectivity and noisy cell division.

KW - CONVERGENT EXTENSION

KW - CELL-MIGRATION

KW - MODEL

KW - MECHANICS

KW - SHAPE

KW - GASTRULATION

KW - SIMULATION

KW - EPITHELIA

KW - INSIGHTS

KW - BEHAVIOR

U2 - 10.1103/PhysRevResearch.4.023171

DO - 10.1103/PhysRevResearch.4.023171

M3 - Journal article

VL - 4

JO - Physical Review Research

JF - Physical Review Research

SN - 2643-1564

IS - 2

M1 - 023171

ER -