A phenylpropanoid, a slovenolide, two sulphur-containing germacranes and Ca+2-ATPase inhibitors from Thapsia villosa
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A phenylpropanoid, a slovenolide, two sulphur-containing germacranes and Ca+2-ATPase inhibitors from Thapsia villosa. / Rubal, Juan J; Moreno-Dorado, F Javier; Guerra, Francisco M; Jorge, Zacarías D; Galán, María del Carmen; Salido, Ginés M; Christensen, Søren Brøgger; Søhoel, Helmer; Massanet, Guillermo M.
In: Planta Medica, Vol. 76, No. 3, 2010, p. 284-290.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - A phenylpropanoid, a slovenolide, two sulphur-containing germacranes and Ca+2-ATPase inhibitors from Thapsia villosa
AU - Rubal, Juan J
AU - Moreno-Dorado, F Javier
AU - Guerra, Francisco M
AU - Jorge, Zacarías D
AU - Galán, María del Carmen
AU - Salido, Ginés M
AU - Christensen, Søren Brøgger
AU - Søhoel, Helmer
AU - Massanet, Guillermo M
N1 - Keywords: Thapsia villosa; Apiaceae; Germacranes; Phenylpropanoids; Slovenolides; Thapsigargins; Transtaganolides; Ca+2-ATPase inhibitors
PY - 2010
Y1 - 2010
N2 - A phenylpropanoid 1, a slovenolide 2, and two germacranes bearing a methylthiopropenoate moiety, 3 and 4, along with twenty known metabolites have been isolated from the roots of THAPSIA VILLOSA var. VILLOSA L. The structures of two known phenylpropanoids 5 and 6 have been corrected. Compounds 7 and 8 showed activity as potential inhibitors of the sarco- and endoplasmic Ca (2+)-dependent ATPases (SERCA) pump. Compounds 9, 10 and 11 increased significantly the cytoplasmic free calcium concentration ([Ca (2+)] (c)) in human platelets in a concentration-dependent manner.
AB - A phenylpropanoid 1, a slovenolide 2, and two germacranes bearing a methylthiopropenoate moiety, 3 and 4, along with twenty known metabolites have been isolated from the roots of THAPSIA VILLOSA var. VILLOSA L. The structures of two known phenylpropanoids 5 and 6 have been corrected. Compounds 7 and 8 showed activity as potential inhibitors of the sarco- and endoplasmic Ca (2+)-dependent ATPases (SERCA) pump. Compounds 9, 10 and 11 increased significantly the cytoplasmic free calcium concentration ([Ca (2+)] (c)) in human platelets in a concentration-dependent manner.
KW - Former Faculty of Pharmaceutical Sciences
U2 - 10.1055/s-0029-1186056
DO - 10.1055/s-0029-1186056
M3 - Journal article
C2 - 19708003
VL - 76
SP - 284
EP - 290
JO - Planta Medica
JF - Planta Medica
SN - 0032-0943
IS - 3
ER -
ID: 14119578