A phenylpropanoid, a slovenolide, two sulphur-containing germacranes and Ca+2-ATPase inhibitors from Thapsia villosa
Research output: Contribution to journal › Journal article › Research › peer-review
A phenylpropanoid 1, a slovenolide 2, and two germacranes bearing a methylthiopropenoate moiety, 3 and 4, along with twenty known metabolites have been isolated from the roots of THAPSIA VILLOSA var. VILLOSA L. The structures of two known phenylpropanoids 5 and 6 have been corrected. Compounds 7 and 8 showed activity as potential inhibitors of the sarco- and endoplasmic Ca (2+)-dependent ATPases (SERCA) pump. Compounds 9, 10 and 11 increased significantly the cytoplasmic free calcium concentration ([Ca (2+)] (c)) in human platelets in a concentration-dependent manner.
Original language | English |
---|---|
Journal | Planta Medica |
Volume | 76 |
Issue number | 3 |
Pages (from-to) | 284-290 |
ISSN | 0032-0943 |
DOIs | |
Publication status | Published - 2010 |
Bibliographical note
Keywords: Thapsia villosa; Apiaceae; Germacranes; Phenylpropanoids; Slovenolides; Thapsigargins; Transtaganolides; Ca+2-ATPase inhibitors
- Former Faculty of Pharmaceutical Sciences
Research areas
ID: 14119578