Radiation-Induced Toxicity Risks in Photon Versus Proton Therapy for Synchronous Bilateral Breast Cancer

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Radiation-Induced Toxicity Risks in Photon Versus Proton Therapy for Synchronous Bilateral Breast Cancer. / Stick, Line Bjerregaard; Jensen, Maria Fuglsang; Bentzen, Soren M.; Kamby, Claus; Lundgaard, Anni Young; Maraldo, Maja Vestmo; Offersen, Birgitte Vrou; Yu, Jen; Vogelius, Ivan Richter.

In: International Journal of Particle Therapy, Vol. 8, No. 4, 13.03.2022, p. 1-13.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Stick, LB, Jensen, MF, Bentzen, SM, Kamby, C, Lundgaard, AY, Maraldo, MV, Offersen, BV, Yu, J & Vogelius, IR 2022, 'Radiation-Induced Toxicity Risks in Photon Versus Proton Therapy for Synchronous Bilateral Breast Cancer', International Journal of Particle Therapy, vol. 8, no. 4, pp. 1-13. https://doi.org/10.14338/IJPT-21-00023.1

APA

Stick, L. B., Jensen, M. F., Bentzen, S. M., Kamby, C., Lundgaard, A. Y., Maraldo, M. V., Offersen, B. V., Yu, J., & Vogelius, I. R. (2022). Radiation-Induced Toxicity Risks in Photon Versus Proton Therapy for Synchronous Bilateral Breast Cancer. International Journal of Particle Therapy, 8(4), 1-13. https://doi.org/10.14338/IJPT-21-00023.1

Vancouver

Stick LB, Jensen MF, Bentzen SM, Kamby C, Lundgaard AY, Maraldo MV et al. Radiation-Induced Toxicity Risks in Photon Versus Proton Therapy for Synchronous Bilateral Breast Cancer. International Journal of Particle Therapy. 2022 Mar 13;8(4):1-13. https://doi.org/10.14338/IJPT-21-00023.1

Author

Stick, Line Bjerregaard ; Jensen, Maria Fuglsang ; Bentzen, Soren M. ; Kamby, Claus ; Lundgaard, Anni Young ; Maraldo, Maja Vestmo ; Offersen, Birgitte Vrou ; Yu, Jen ; Vogelius, Ivan Richter. / Radiation-Induced Toxicity Risks in Photon Versus Proton Therapy for Synchronous Bilateral Breast Cancer. In: International Journal of Particle Therapy. 2022 ; Vol. 8, No. 4. pp. 1-13.

Bibtex

@article{a4712f49b5f74969bd5847e97546408f,
title = "Radiation-Induced Toxicity Risks in Photon Versus Proton Therapy for Synchronous Bilateral Breast Cancer",
abstract = "Purpose: This study compares photon and proton therapy plans for patients with synchronous bilateral early breast cancer and estimates risks of early and late radiationinduced toxicities.Materials and Methods: Twenty-four patients with synchronous bilateral early breast cancer receiving adjuvant radiation therapy using photons, 3-dimensional conformal radiation therapy or volumetric modulated arc therapy, were included and competing pencil beam scanning proton therapy plans were created. Risks of dermatitis, pneumonitis, acute esophageal toxicity, lung and breast fibrosis, hypothyroidism, secondary lung and esophageal cancer and coronary artery events were estimated using published dose-response relationships and normal tissue complication probability (NTCP) models.Results: The primary clinical target volume V95% and/or nodal clinical target volume V90% were less than 95% in 17 photon therapy plans and none of the proton plans. Median NTCP of radiation dermatitis > grade 2 was 18.3% (range, 5.4-41.7) with photon therapy and 58.4% (range, 31.4-69.7) with proton therapy. Median excess absolute risk (EAR) of secondary lung cancer at age 80 for current and former smokers was 4.8% (range, 0.0-17.0) using photons and 2.7% (range, 0.0-13.6) using protons. Median EAR of coronary event at age 80, assuming all patients have preexisting cardiac risk factors, was 1.0% (range, 0.0-5.6) with photons and 0.2% (range, 0.0-1.3) with protons.Conclusion: Proton therapy plans improved target coverage and reduced risk of coronary artery event and secondary lung cancer while increasing the risk of radiation dermatitis.",
keywords = "proton therapy, bilateral breast cancer, treatment planning, bioeffect modeling, normal tissue complication probability, INTERNAL MAMMARY, LUNG-CANCER, RADIOTHERAPY, IRRADIATION, WOMEN, HEART, COMPLICATIONS, DELINEATION, RECURRENCE, CARCINOMA",
author = "Stick, {Line Bjerregaard} and Jensen, {Maria Fuglsang} and Bentzen, {Soren M.} and Claus Kamby and Lundgaard, {Anni Young} and Maraldo, {Maja Vestmo} and Offersen, {Birgitte Vrou} and Jen Yu and Vogelius, {Ivan Richter}",
year = "2022",
month = mar,
day = "13",
doi = "10.14338/IJPT-21-00023.1",
language = "English",
volume = "8",
pages = "1--13",
journal = "International Journal of Particle Therapy",
issn = "2331-5180",
publisher = "Allen Press Inc.",
number = "4",

}

RIS

TY - JOUR

T1 - Radiation-Induced Toxicity Risks in Photon Versus Proton Therapy for Synchronous Bilateral Breast Cancer

AU - Stick, Line Bjerregaard

AU - Jensen, Maria Fuglsang

AU - Bentzen, Soren M.

AU - Kamby, Claus

AU - Lundgaard, Anni Young

AU - Maraldo, Maja Vestmo

AU - Offersen, Birgitte Vrou

AU - Yu, Jen

AU - Vogelius, Ivan Richter

PY - 2022/3/13

Y1 - 2022/3/13

N2 - Purpose: This study compares photon and proton therapy plans for patients with synchronous bilateral early breast cancer and estimates risks of early and late radiationinduced toxicities.Materials and Methods: Twenty-four patients with synchronous bilateral early breast cancer receiving adjuvant radiation therapy using photons, 3-dimensional conformal radiation therapy or volumetric modulated arc therapy, were included and competing pencil beam scanning proton therapy plans were created. Risks of dermatitis, pneumonitis, acute esophageal toxicity, lung and breast fibrosis, hypothyroidism, secondary lung and esophageal cancer and coronary artery events were estimated using published dose-response relationships and normal tissue complication probability (NTCP) models.Results: The primary clinical target volume V95% and/or nodal clinical target volume V90% were less than 95% in 17 photon therapy plans and none of the proton plans. Median NTCP of radiation dermatitis > grade 2 was 18.3% (range, 5.4-41.7) with photon therapy and 58.4% (range, 31.4-69.7) with proton therapy. Median excess absolute risk (EAR) of secondary lung cancer at age 80 for current and former smokers was 4.8% (range, 0.0-17.0) using photons and 2.7% (range, 0.0-13.6) using protons. Median EAR of coronary event at age 80, assuming all patients have preexisting cardiac risk factors, was 1.0% (range, 0.0-5.6) with photons and 0.2% (range, 0.0-1.3) with protons.Conclusion: Proton therapy plans improved target coverage and reduced risk of coronary artery event and secondary lung cancer while increasing the risk of radiation dermatitis.

AB - Purpose: This study compares photon and proton therapy plans for patients with synchronous bilateral early breast cancer and estimates risks of early and late radiationinduced toxicities.Materials and Methods: Twenty-four patients with synchronous bilateral early breast cancer receiving adjuvant radiation therapy using photons, 3-dimensional conformal radiation therapy or volumetric modulated arc therapy, were included and competing pencil beam scanning proton therapy plans were created. Risks of dermatitis, pneumonitis, acute esophageal toxicity, lung and breast fibrosis, hypothyroidism, secondary lung and esophageal cancer and coronary artery events were estimated using published dose-response relationships and normal tissue complication probability (NTCP) models.Results: The primary clinical target volume V95% and/or nodal clinical target volume V90% were less than 95% in 17 photon therapy plans and none of the proton plans. Median NTCP of radiation dermatitis > grade 2 was 18.3% (range, 5.4-41.7) with photon therapy and 58.4% (range, 31.4-69.7) with proton therapy. Median excess absolute risk (EAR) of secondary lung cancer at age 80 for current and former smokers was 4.8% (range, 0.0-17.0) using photons and 2.7% (range, 0.0-13.6) using protons. Median EAR of coronary event at age 80, assuming all patients have preexisting cardiac risk factors, was 1.0% (range, 0.0-5.6) with photons and 0.2% (range, 0.0-1.3) with protons.Conclusion: Proton therapy plans improved target coverage and reduced risk of coronary artery event and secondary lung cancer while increasing the risk of radiation dermatitis.

KW - proton therapy

KW - bilateral breast cancer

KW - treatment planning

KW - bioeffect modeling

KW - normal tissue complication probability

KW - INTERNAL MAMMARY

KW - LUNG-CANCER

KW - RADIOTHERAPY

KW - IRRADIATION

KW - WOMEN

KW - HEART

KW - COMPLICATIONS

KW - DELINEATION

KW - RECURRENCE

KW - CARCINOMA

U2 - 10.14338/IJPT-21-00023.1

DO - 10.14338/IJPT-21-00023.1

M3 - Journal article

C2 - 35530186

VL - 8

SP - 1

EP - 13

JO - International Journal of Particle Therapy

JF - International Journal of Particle Therapy

SN - 2331-5180

IS - 4

ER -

ID: 286854897